• ABT-263 (Navitoclax): Dissecting Nuclear-Mitochondrial Ap...

  2025-09-19

  Explore how ABT-263 (Navitoclax), a potent Bcl-2 family inhibitor, enables advanced mechanistic studies of nuclear-mitochondrial apoptotic signaling in cancer biology. This article highlights emerging insights into caspase-dependent apoptosis research, integrating recent discoveries about RNA Pol II-driven cell death pathways.

• Maximizing mRNA Delivery and Bioluminescent Reporting wit...

  2025-09-18

  Explore how EZ Cap™ Firefly Luciferase mRNA with Cap 1 structure advances mRNA delivery, translation efficiency assays, and in vivo bioluminescence imaging. This comprehensive review highlights the molecular features, experimental applications, and recent delivery innovations for robust gene regulation reporter assays.

• The lactam emerged as lead candidate due to its

  2025-03-03

  

  The lactam (6) emerged as lead candidate due to its high selectivity, outstanding potency (against ALK or in clinically known ALK mutants), low in vitro clearance, and low efflux potential. The lactam (6) was selected for further profiling against the resistant ALK mutants. Preclinical rat pharmacok

• In conclusion phenolic hydroxyl was introduced not

  2025-03-03

  

  In conclusion, phenolic hydroxyl was introduced not only to C3 side chain but also to C6 or C7 position of the quinoxalinone core, resulting in a new group of ARIs candidates exhibiting antioxidant activity. Biological activity tests suggested that compounds were not only sufficient to inhibit ALR2

• The present study determined the effect of DCA

  2025-03-03

  

  The present study determined the effect of DCA on VSMC calcification in vitro and in atherosclerotic ApoE-/- mice in vivo. We found that Membrane impermeable dye non-toxic concentrations of DCA, did not affect VSMC viability, induced calcification of VSMC in culture and increased atherosclerotic vas

• With one exception all receptors for dopamine DA serotonin h

  2025-03-03

  

  With one exception, all receptors for dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT), and norepinephrine are metabotropic receptors. The five metabotropic DA receptors (D1–D5) in the CNS are involved in motivation, pleasure, cognition, learning, memory, fine motor control, and modulate neuroen

• G has been shown to participate in various MT

  2025-03-03

  

  Gβγ has been shown to participate in various MT-dependent processes such as cell growth and differentiation [15,[21], [22], [23], [24], [25], [26]]. G-protein β-subunit anti-sense oligonucleotides have been shown to inhibit cell proliferation and cause disorganization of the mitotic spindle in mamma

• ionophore In conclusion we have shown that mGlu

  2025-03-03

  

  In conclusion, we have shown that mGlu7 receptors negatively regulate α1-adrenergic receptor signalling in heterologous expression systems, ionophore tissue and living animals. This interaction might represent a protective mechanism aimed at restraining an excessive activation of noradrenergic tran

• The synthetic route to M

  2025-03-03

  

  The synthetic route to M100907 developed by Rice was utilized, however, the chiral resolution was carried out at an earlier stage to provide the possibility of introducing different substituents onto the piperidinyl group. The conditions for this resolution were different from previously reported.

• False positivity of Anti AChR Ab titers

  2025-03-03

  

  False positivity of Anti-AChR Ab titers, due to cross reactivity with bungarotoxin, has previously been demonstrated. One such study reported that patients with amyotrophic lateral sclerosis, who had received long term snake venom therapy, had developed antibodies to bungarotoxin and hence demonstra

• Although effects of low concentrations

  2025-03-03

  

  Although effects of low concentrations of agonist were not as thoroughly documented for heteromeric receptors such as the major Alisol A α4β2 nAChR, a similar mechanism of action was described to explain the potentiation of these receptors with low concentrations of acetylcholine-esterase-inhibiting

• br COX and LOX in post mortem AD brain

  2025-03-03

  

  COX and 5-LOX in post-mortem AD brain Minghetti (2004) reviewed the findings on COX-2 mRNA levels in AD brains, pointing out that the available evidence demonstrated either decreased or increased levels, possibly because of the short half-life of COX-2 transcripts or individual variability. Histo

• Functional enhancers are often composed of binding motifs of

  2025-03-01

  

  Functional enhancers are often composed of binding motifs of multiple key transcription factors to confer spatial and temporal regulation of genes in a certain context. In the uterus, the difference between the number of genes that have associated PGR occupancy and that of progesterone responsive ge

• br Materials and methods br Results br Discussion

  2025-03-01

  

  Materials and methods Results Discussion Japanese encephalitis caused by JEV is characterized by PHA-767491 neuron death. However, the underlying mechanism is not fully understood. We and other researchers have demonstrated that JEV induces apoptosis by ER stress-mediated IRE1/JNK and ROS-m

• Recently AFF was used to convert an FN

  2025-03-01

  

  Recently, AFF was used to convert an FN3-based binder specific to the Src homology 2 (SH2) domain of cAbl kinase into an allosterically regulated, intermolecular fluorescent switch (Figure 2D). Binding to cAbl kinase co-operatively stabilized the assembly of the FN3-based binder from two partial fra

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