• br Experimental br Declaration of interest

  2019-07-15

  

  Experimental Declaration of interest Introduction Material and methods Results and discussion Conclusion By screening the NMR TCS 359 library an initial hit was found for an inhibitor of the PPI between the α-β subunits of CK2 with an IC50 of 900 μM. This compound was modified and

• The major concern of PDE I use

  2019-07-15

  

  The major concern of PDE-5-I use in liver cirrhosis is the potentially harmful effect on systemic blood pressure. Data of clinical studies are conflicting [27], [30], [31], [32], but available patient details suggest that in advanced liver cirrhosis, PDE-5-Is lower systemic blood pressure to a great

• br Progestogens and venous thromboembolism clinical data br

  2019-07-15

  

  Progestogens and venous thromboembolism: clinical data Progestogens and haemostatis: biological studies For many years, the effect of HT on haemostatis has been largely investigated in observational studies as well as in high evidence level studies among users of oral and transdermal estrogens

• The need for dedicated DAPT updates is

  2019-07-15

  

  The need for dedicated DAPT updates is well justified by the large amount of data and new information generated in the field over the past few years. As expected, the ACC/AHA and ESC updates contain large areas of overlap as well as some differences. Differences were largely explained by the differe

• ERR is present early in

  2019-07-15

  

  ERRβ is present early in the developing placenta in a subset of Senegenin in extra-embryonic ectoderm destined to make up the chorion.19, 20 ERRβ is likely essential for reproduction. ERRβ expression is essential for the maintenance of pluripotency and self-renewal potential in mouse embryonic stem

• In normal chow fed mice EP deficiency also

  2019-07-15

  

  In normal chow fed mice, EP4 deficiency also decreased the expression of CYP8B1, the downstream target of CYP7A1. Similarly, knockdown of EP4 with small interfering RNA reduced the expression of CYP8B1 in HepG2 cells. Therefore, it was anticipated that there would be an increased expression of CYP8B

• The four other mutations S T V I

  2019-07-13

  The four other mutations (S281T, V317I, T328A and A329S) were not detected in the absence of the A286S.

• Molecular modelling studies were performed on the hDHFR inhi

  2019-07-12

  Molecular modelling studies were performed on the hDHFR inhibitors identified (1, 11, 13, 14, 16, 25 and 32) to explore the structural basis of the interaction between the mentioned compounds and the human enzyme.

• Author Contributions Acknowledgments Introduction Many ant

  2019-07-11

  Author Contributions Acknowledgments Introduction Many anticancer agents bind covalently to DNA, introduce bulky adducts, and inhibit DNA metabolic processes including repair, replication and transcription.1., 2., 3.

• Introduction Biocatalysis can be used to synthesize chiral

  2019-07-10

  Introduction Biocatalysis can be used to synthesize chiral building blocks, such as monomers for polymer materials, and precursors for pharmaceuticals [[1], [2], [3], [4]].

• Anaesthetized mice of one eNOS

  2019-07-09

  Anaesthetized mice of one eNOS-KO strain showed a paradoxical decrease in blood pressure (BP) in response to i.p. administration of the NOS-inhibitor L-NA suggesting a role for non-endothelial isoforms of NOS in maintaining BP [1].

• Introduction Phosphorus P is an important nutrient for plant

  2019-07-08

  Introduction Phosphorus (P) is an important nutrient for plant growth; however, in many regions of the world soils are low in plant-available P (Holford, 1997).

• An increased CK activity was found in septal

  2019-07-05

  An increased CK2 activity was found in septal neuronal surface antigen (208-215) [Hepatitis B Virus] dissected from rat embryos after hypoglycemia [36].

• HEK cells stably transfected with CysLT were stimulated with

  2019-07-04

  HEK-293 transferrin fragment stably transfected with CysLT1 were stimulated with LTD and internalization was studied by confocal microscopy, FACS or cell-surface ELISA.

• The key difference between the membrane zymography

  2019-07-03

  The key difference between the membrane zymography and classical measurements of enzyme activities in soil slurries is the enzyme-substrate accessibility.

14362 records 957/958 page Previous Next First page 上5页 956957958