Author Contributions Acknowledgments Introduction Many ant

2019-07-11

Author Contributions Acknowledgments Introduction Many anticancer agents bind covalently to DNA, introduce bulky adducts, and inhibit DNA metabolic processes including repair, replication and transcription.1., 2., 3.

Introduction Biocatalysis can be used to synthesize chiral

2019-07-10

Introduction Biocatalysis can be used to synthesize chiral building blocks, such as monomers for polymer materials, and precursors for pharmaceuticals [[1], [2], [3], [4]].

Anaesthetized mice of one eNOS

2019-07-09

Anaesthetized mice of one eNOS-KO strain showed a paradoxical decrease in blood pressure (BP) in response to i.p. administration of the NOS-inhibitor L-NA suggesting a role for non-endothelial isoforms of NOS in maintaining BP [1].

Introduction Phosphorus P is an important nutrient for plant

2019-07-08

Introduction Phosphorus (P) is an important nutrient for plant growth; however, in many regions of the world soils are low in plant-available P (Holford, 1997).

An increased CK activity was found in septal

2019-07-05

An increased CK2 activity was found in septal neuronal surface antigen (208-215) [Hepatitis B Virus] dissected from rat embryos after hypoglycemia [36].

HEK cells stably transfected with CysLT were stimulated with

2019-07-04

HEK-293 transferrin fragment stably transfected with CysLT1 were stimulated with LTD and internalization was studied by confocal microscopy, FACS or cell-surface ELISA.

The key difference between the membrane zymography

2019-07-03

The key difference between the membrane zymography and classical measurements of enzyme activities in soil slurries is the enzyme-substrate accessibility.

The EGFR belongs to the ErbB family of

2019-07-02

The EGFR belongs to the ErbB family of receptor tyrosine kinases (RTKs), comprised of four members: EGFR (ErbB1, HER1), HER2 (ErbB2), HER3 (ErbB3) and HER4 (ErbB4) [24].

A summary of the drug CDK hydrophobic hydrogen bonding

2019-07-01

A summary of the drug-CDK2/6/9 hydrophobic (Φ), hydrogen-bonding (H), and polar-bonding (P) interactions based upon the KLIFS residue numbers is provided in Table 5.

Es en virtud de estas afirmaciones

2019-06-29

Es en virtud de estas afirmaciones que propongo retomar una perspectiva literaria para pensar los modos diversos de concebir la representación, así como atender GnRH Associated Peptide (GAP) (1-13), human la insistencia con que se acude a “lo real” (e incluso al “realismo”) para caracterizar las crónicas de la conquista en general y la de Bernal Díaz en particular.

br Practical management of perioperative anticoagulation and

2019-06-28

Practical management of perioperative anticoagulation and antiplatelet therapy in CIED surgery By integrating the current literature and the experience from our own practice, we developed a practical algorithm recently to guide the perioperative management of anticoagulation and antiplatelet therapy in patients on warfarin therapy undergoing CIED surgery (Fig.2).

years ago published a groundbreaking and taboo breaking Seri

2019-06-27

5 years ago, published a groundbreaking (and taboo-breaking) Series on stillbirths. Its powerful mix of advocacy and hard data attracted more media attention than perhaps any other Series, and made waves on numerous levels, from the individual to the intergovernmental. Working closely with countries and WHO, the Series authors fought to bring “out of the shadows” the unacceptable toll of intrapartum stillbirths in low-income countries, the addressable differences in stillbirth rates between countries with advanced health systems, and the deplorable absence of such devastating events from global tracking efforts such as those of the UN, the Millennium Development Goals, and the Global Burden of Disease.

First progress towards the targets should be measured throug

2019-06-27

First, progress towards the 2020 targets should be measured through collation, presentation, and analysis of standardised core metrics that track country progress.

Hello world!

2018-07-29