• Funding sources This study was funded

  2019-09-24

  

  Funding sources This study was funded by European Community’s Seventh Framework Programme under grant agreement No. 305662 (Project: Community-based scheduled screening and treatment of malaria in pregnancy for improved maternal and infant health: a cluster-randomized trial ‘COSMIC’). Acknowledg

• Bradykinin acetate pathway Herein we explored by docking stu

  2019-09-24

  

  Herein, we explored by docking studies the effectiveness of replacing the dimethyl substitution at C (6) of dihydrotriazine with a folded azaspiro-containing substituent, along with the introduction of differently substituted phenyl- and benzyl-rings or alkyl chains, linked at the position 1 of the

• The efficacy of A in the ob ob

  2019-09-24

  

  The efficacy of A-922500 in the ob/ob mouse model is of particular interest for two reasons. One of the most striking features of the DGAT-1 deficient mouse phenotype is the resistance to diet-induced obesity (Smith et al., 2000). However, Octopamine HCl clinical of DGAT-1 in leptin deficient ob/ob

• In this study we have developed and investigated three NADPH

  2019-09-24

  

  In this study we have developed and investigated three NADPH-regenerating fusion partners with two different enzyme systems: a BVMO and an ADH. With the exception of one fusion construct (StGDH with LbADH), all fusion estriol and resulted in good soluble expression as well as fully functional as se

• Dgat mice however had less adipose tissue as reflected

  2019-09-23

  

  Dgat−/− mice, however, had less adipose tissue, as reflected by lower total fat pad weights and body triglyceride content. Because of these findings, we hypothesized that, although Dgat−/− mice could make triglycerides through non-DGAT pathway(s), their triglyceride synthesis capacity might not be e

• Multiple protein species are known to

  2019-09-23

  

  Multiple protein species are known to naturally exist for the transmembrane receptors DDR1 and DDR2. Five splice variants have been characterized for DDR1 (“a” through “e”). The d and e isoforms lack the intracellular kinase domain of DDR1. The splicing of DDR1 to various extents has been reported i

• Although the crystal structures of Atg

  2019-09-23

  

  Although the crystal structures of Atg4C and Atg4D are not available, their three dimensional structures can be acquired by homology modeling, using the structure of Atg4B as a template (Zhang, Li, Ouyang, Liu, & Cheng, 2016). In that model, the catalytic triad is conserved (Cys110/Asp345/His347 for

• Rambabu et al reported A series of novel

  2019-09-23

  

  Rambabu et al. reported A series of novel N-substituted 2-(2-oxo-2H-chromen-4-yloxy)propanamide derivatives synthesized from readily available 4-hydroxy coumarin to the corresponding ethyl 2-(2-oxo-2H-chromen-4-yloxy)propanoate followed by hydrolysis and further reacted with different substituted am

• ClC is a member of the voltage gated chloride

  2019-09-23

  

  ClC-3 is a member of the voltage-gated chloride channel superfamily and has many roles in cell proliferation, apoptosis, PCI-32765 progression and so on (Dai et al., 2005). A growing number of studies showed that ClC-3 encoded a volume-regulated Cl− channel (ICl,Vol) in heart, that could contribute

• br Substrate characterization of candidate peptide reporters

  2019-09-23

  

  Substrate characterization of candidate peptide reporters in a library Measurement of resistance to intracellular proteases Use of capillary zone electrophoresis for assay readout Selection of lead peptide from small library screen Characterization of final reporter Additional modif

• TRAM-34 In this study we were able derive new insights into

  2019-09-23

  

  In this study, we were able derive new insights into the biology of DDR2 including the demonstration that cellular tyrosine phosphorylated proteins co-localise with DDR2 and exogenously added collagen I (Fig. 1G). This finding suggests that similar to the focal adhesion complexes associated with int

• br Materials and methods br

  2019-09-23

  

  Materials and methods Results Discussion In this study, we employed a liquid chromatography mass spectrometry (LC–MS)-based metabolomic approach to profile GEF metabolism and bioactivation in human and mouse liver microsomes. Metabolomic approaches rendered us readily screen out the GEF-rel

• Methods br Results br Discussion It is well

  2019-09-23

  

  Methods Results Discussion It is well established that CRSwNP is characterized by TH2 inflammation and eosinophilia.22, 27 Yet it is becoming increasingly apparent that B cells might play an important role in the inflammatory response within the sinus tissue of patients with CRSwNP.8, 9 The l

• br Results br Discussion The

  2019-09-23

  

  Results Discussion The structures presented here were solved at high used the survey and show in detail how DDR1 achieves high affinity for imatinib and ponatinib, respectively. Both type II inhibitors bind in their more potent extended conformations to the inactive DFG-out conformation of th

• The mechanisms in the central nervous system CNS controlling

  2019-09-23

  

  The mechanisms in the central nervous system (CNS) controlling the sympathetic tone of the Hydroxysafflor yellow A are associated to behavioral strategies, such as those involved in response to stress. In this regard, morphine withdrawal induces profound and severe stress reactions evidenced by enh

14282 records 913/953 page Previous Next First page 上5页 911912913914915 下5页 Last page