• The main oxidative stress factor in COPD

  2020-07-27

  

  The main oxidative stress factor in COPD is related to the reduction in endogenous concentrations of antioxidants, and many of the genes that encode these antioxidants are regulated by the transcription factor Nrf2 [4,34,44]. In this way, exposure to oxidants upregulates endogenous antioxidants in a

• Introduction Maintenance of genome integrity is

  2020-07-27

  

  Introduction Maintenance of genome integrity is essential for life, and faithful DNA replication and repair ensure this. One of the most important parameters for DNA maintenance is the regulation of optimal concentrations of the four 5′-deoxyribonucleoside-triphosphates (dNTPs) the precursors for D

• br Experimental Procedures DNA synthesis

  2020-07-27

  

  Experimental Procedures DNA synthesis reagents were purchased from Glen Research (Sterling, VA). A solution of 0.1 M triethylamine acetate (TEAA) (pH 6.5) was used as HPLC buffer A, and HPLC-grade acetonitrile from Oceanpak (Sweden) was used as HPLC buffer B. All other chemicals were obtained fro

• LigA inhibitors have been reported by

  2020-07-27

  

  LigA inhibitors have been reported by several groups. Bayer reported a series of potent pyridochromanone inhibitors of LigA. AstraZeneca reported a series of potent adenosine based inhibitors. There have also been reports of inhibitors from a number of autotaxin inhibitor including: arylamino acids

• Previous studies from our laboratory have demonstrated that

  2020-07-27

  

  Previous studies from our laboratory have demonstrated that CysLT1R mRNA and protein expression can be upregulated by T2-type cytokines (IL-13, IL-4, and IL-5) in monocytes, macrophages, and eosinophilic HL-60 cells., To our knowledge, however, there are no studies on interactions of cytokines (such

• psora Fruits are specialized organs that protect ovules

  2020-07-27

  

  Fruits are specialized organs that protect ovules and seeds, promote mature seed dispersal, and provide additional food and nutritional source. Researchers and breeders therefore pay much attention to fruit quality and yield (Ariizumi et al., 2013; Azzi et al., 2015; Mu et al., 2017; Xie et al., 201

• Ro 5-3335 CXCL and CXCR have recently been described in cart

  2020-07-27

  

  CXCL16 and CXCR6 have recently been described in cartilaginous fish (Nomiyama et al., 2011, Venkatesh et al., 2014). In humans, the CXCR6 gene resides upstream of the FYCO1 gene in chromosome 3 and is clustered with several other inflammatory chemokine receptors including XCR1, CCR1–3, CCR5, CCR8 an

• Epidemiology works support the adverse influence of stress i

  2020-07-27

  

  Epidemiology works support the adverse influence of stress in the development and/or aggravation of gastrointestinal disorders such as inflammatory bowel disease (IBD) and colon cancer [2], [3], [4], [5], [6]. Colitis associated cancer (CAC) is a subtype of colon cancer that is preceded by clinicall

• br Chk and Chk mediated signaling

  2020-07-25

  

  Chk 1 and Chk 2 mediated signaling act as a barrier to tumorigenesis It was hypothesized recently that early events during tumorigenesis, such as the overexpression of oncogenes, lead to a DNA-damage response which, in turn halts tumor progression [44], [45], [46]. The DNA-damage response is prop

• fluvastatin TKI discontinuation studies demonstrate that a p

  2020-07-25

  

  TKI discontinuation studies demonstrate that a portion of TKI-treated CML patients remain in remission for up to 3 years, although long-term risk assessment is still necessary (Bansal and Radich, 2016). The majority of CML patients depend on lifetime TKI treatment, and substantial efforts have been

• Enzyme mimics belong to a type of rising catalysts

  2020-07-25

  

  Enzyme mimics belong to a type of rising catalysts which show the similar function with their corresponding natural enzymes [20], [21], [22], [23], [24], [25], [26], [27], although their structures are different from natural enzymes. In the area of prodrug activation, the widely-used enzyme mimics a

• br Experimental section br Acknowledgments MIN cells were

  2020-07-25

  

  Experimental section Acknowledgments MIN6 cells were kindly provided by Dr. Junichi Miyazaki, Osaka University. This research was supported in part by the Ministry of Education, Culture, Sports, Science and Technology of Japan (JP16H05099 and JP18H04609 to K.H., and JP16H06574 to T.U.), SENTAN

• br Expression data suggest involvement of

  2020-07-25

  

  Expression data suggest involvement of additional TRIMs in heart function Given the complexity of the cardiac function, involved molecular pathways and processes, and the fact that only a few of the TRIMs have thus far been shown to have a cardiac role, we hypothesized that there would be more TR

• DHODH activity has been traditionally

  2020-07-25

  

  DHODH activity has been traditionally measured with the standard colorimetric assay that monitors 2,6-dichloroindophenol (DCIP) reduction as absorbance decrease at 600 nm . This assay has permitted the identification of several families of DHODH inhibitors in a successful high-throughput screening (

• The data from drug screening in

  2020-07-25

  

  The data from drug screening in P. berghei (Fig. 3D) provide proof of concept that chemogenomic profiling can be accomplished in P. berghei in the same manner as P. falciparum, in that significant increases in the EC50 ratio were found only for antifolate drugs in the parasite with attenuated TgDHFR

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