• Recently CFS has been included

  2021-11-02

  

  Recently, CFS has been included in the group “low cystine and glutamine syndromes,” which are characterized by a combination of abnormally low plasma levels of these two aminoacids, as well as reduced natural killer cell activity, and increased rates of urea production [13]. Some studies indicated

• br GSNOR activity and functions The

  2021-11-02

  

  GSNOR activity and functions The identification of the enzyme responsible for GSNO decomposition dates back to 1998, when Jensen and colleagues described an NAD(P)H-dependent GSNO catabolizing activity in cytosolic fractions obtained from rat liver [16]. Upon purification, they identified this en

• br Medium and long chain fatty acid

  2021-11-02

  

  Medium- and long-chain fatty emca receptors Clinical studies of ω3 fatty acids Clinical studies have established that dietary intake of ω3 fatty acids should be around 4g/day for treating very high triglyceride levels (≥5.7mmol/L) [36]. Low-dose supplementation with EPA + DHA (400mg/day) or A

• A few methods have been developed to separate

  2021-11-02

  

  A few methods have been developed to separate and prepare compounds from L. chinensis, such as silica gel column chromatography [5,6] and high-performance liquid chromatography (HPLC) [7]. Silica gel column chromatography is still used for its simple equipment and low cost. However, this method is o

• 98 2 After brain injury adenosine levels rapidly increase in

  2021-11-02

  

  After brain injury, adenosine levels rapidly increase in the brain [9,10]. As shown in our previous studies, the increased adenosine concentration acts on adenosine A2A receptors (A2ARs), increasing post-traumatic glutamate levels in the brain and exacerbating the severity of injuries [11,12]. Accor

• Ion dependence of mGluRs activity has

  2021-11-02

  

  Ion dependence of mGluRs activity has been previously reported, notably to Ca2+ and Cl− (Kuang and Hampson, 2006). While mGlu1 and mGlu3 receptors were demonstrated to be sensitive to Ca2+, Cl− modulation was reported for all mGluRs, with a lesser extent for the mGlu2 receptor (DiRaddo et al., 2014;

• It is an aspiring task to

  2021-11-02

  

  It is an aspiring task to apply the glutamate biosensor for in vivo measurements in IL-10, human recombinant protein tissue. Due to a relatively large size of the electrode used in this work, the biosensor fits only ex vivo applications. However, it is possible to apply platinum microelectrodes 50–

• cAMP is a key secondary messenger which

  2021-11-02

  

  cAMP is a key secondary messenger which transduces extracellular signals at glucagon receptors to intracellular effector molecules. cAMP-protein kinase A (PKA) pathway increases the gene expression of enzymes including phosphoenolpyruvate carboxykinase (PEPCK) and glucose 6-phosphatase (G6Pase) whic

• Moreover after the initial bleaching

  2021-11-02

  

  Moreover, after the initial bleaching of the fluorescent molecules in the targeted cell exposed to laser illumination, the neighboring reservoir KN-93 are expected to give in return new fluorescent ones if the cells are coupled together by gap junction channels. This supposes that the level of fluo

• Recently the classical view of the compartmentalization of

  2021-11-02

  

  Recently, the classical view of the compartmentalization of the plant isoprenoid metabolism has been re-evaluated, following the demonstration of the partial peroxisomal localization of the mevalonic Tiopronin (MVA) pathway, generally regarded as cytosolic. Using GFP-tagging approaches, the last tw

• br STAR Methods br Acknowledgments Funding for this work was

  2021-11-01

  

  STAR★Methods Acknowledgments Funding for this work was provided by grants from the US National Institute of Allergy and Infectious Diseases (NIAID) (R01-AI095068 and UM1-AI068613 to S.H.E. and U24-AI118633 to H.B.L.) and grant OPP1155863 from the Bill and Melinda Gates Foundation to S.J.E. Add

• br Materials and methods br Results br Discussion Genetic an

  2021-11-01

  

  Materials and methods Results Discussion Genetic analyses conducted here were based on specific features of PhyChem indexes for nt dimers extracted to generate a numerical sequence representation, which was used to build models for distinguishing HVR1 variants between CIP and MIP. This data

• br Evolution of multiple GnRH forms and GnRH receptors acros

  2021-11-01

  

  Evolution of multiple GnRH forms and GnRH receptors across vertebrates GnRH is an evolutionary ancient peptide that first appears prior to the protostome-deuterostome split, and is a member of the GnRH-adipokinetic hormone-corazonin superfamily of peptides (Roch et al., 2011, Roch et al., 2014).

• Here we performed TEM and AFM imaging to study APE

  2021-11-01

  

  Here, we performed TEM and AFM imaging to study APE1–DNA interactions. The results showed that APE1 can dynamically polymerize on DNA in an apparently sequence-independent manner. We propose that this protein polymerization allows for scanning of the structural properties of DNA with short residence

• Rare mutations can impair the molecular function of GR

  2021-11-01

  

  Rare mutations can impair the molecular function of GR and alter tissue sensitivity to GCs in humans, resulting in primary generalized GC resistance (PGGR) and hypersensitivity (PGGH) [14]. Familial and sporadic PGGR, or Chrousos Syndrome, is characterized by general and partial insensitivity of tis

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