• pHi regulation in astrocytes has been examined primarily in

  2022-01-17

  

  pHi regulation in astrocytes has been examined primarily in cell culture rather than in situ. Two HCO3−-dependent transporters, NBC and Na+-driven Cl-HCO3 exchange (NDCBE), have been described [10,16], in addition to Cl-HCO3 anion exchange (AE) [96]. Culture studies indicate that NHE is the principa

• With the advent of genome sequencing hexokinase gene sequenc

  2022-01-17

  

  With the advent of genome sequencing, hexokinase gene sequences are now available from a far greater number of vertebrate species, as well as from diverse non-vertebrate animal species. As indicated above, searches of vertebrate genome sequences revealed the existence of a novel fifth member of the

• Analogous to all GPCRs the GLP R

  2022-01-17

  

  Analogous to all GPCRs, the GLP-1R transduces signals from the outside of the cell to the inside by allosterically converting a ligand-binding event to activation of intracellular effectors. The GLP-1R couples to several intracellular effectors and this pleiotropic coupling is physiologically releva

• In case where an extreme loop

  2022-01-17

  

  In case where an extreme loop (of up to 45 nt) is allowed, as in G3 + E3 + XX, however, a G3+GQ loop maximum of 3 was adequate to reach high J-statistic. It continued to increase only up to 6 as the loop maximum. (Fig. 1A) Hence we suggest using a G3+GQ loop maximum between 3 and 6 where an extreme

• LXRs are physiological regulators of

  2022-01-17

  

  LXRs are physiological regulators of cholesterol and lipid metabolism and influence glucose metabolism. In addition, they have been shown to repress transcription of certain pro-inflammatory genes (Jakobsson et al., 2012; Ogawa et al., 2005; Terasaka et al., 2005). Thus, LXRs can either activate or

• This excellent tolerability is especially interesting in the

  2022-01-17

  

  This excellent tolerability is especially interesting in the light of the fact that intravenous administration of liposomal ponatinib was predicted to yield much higher plasma concentrations as compared to the orally administered free drug. In addition, liposomal drug dose in absolute numbers was te

• We have presented evidence that only muscle

  2022-01-17

  

  We have presented evidence that only muscle FBPase is detectable within HL-1 cells. This is consistent with past findings of the Eschrich's group, which showed that in rat heart Oxonic acid potassium salt expression of FBPase is almost exclusively limited to the muscle isozyme [3]. Results of our

• br Experimental br Results and discussions

  2022-01-15

  

  Experimental Results and discussions Conclusions Declaration of interests Acknowledgements Financial support from the National Natural Science Foundation of China (21605089 and 81773483), the Ningbo Municipal Natural Science Foundation (2017A610228 and 2018A610217), the Open Subject o

• br Conclusion br Acknowledgments This research was funded by

  2022-01-15

  

  Conclusion Acknowledgments This research was funded by Tianjin Health Institution Key Projects, grant number 15KG148” and “Tianjin Medical University General Hospital Youth Incubation Fund, grant number ZYYFY2017029”. I would like to express my heartfelt gratitude to Professor Hongtao Zhang fo

• Curcumin is a major yellow

  2022-01-15

  

  Curcumin is a major yellow pigment in turmeric ground rhizome of Curcuma longa Linn, which is used widely as a spice and coloring agent in several foods such as curry, mustard and potato chips as well as cosmetics and drugs (Okada et al., 2001, Joe et al., 2004). Curcumin represents a class of anti-

• br Introduction In the treatment of patients with AIDS and

  2022-01-15

  

  Introduction In the treatment of patients with AIDS and human immunodeficiency virus type 1 (HIV-1), anti-retroviral therapy (ART), which uses anti-HIV drugs such as protease inhibitors, integrase inhibitors and reverse transferase inhibitors, has made a major contribution. There are still some s

• Recently higher grade varicoceles have been reported

  2022-01-15

  

  Recently, higher-grade varicoceles have been reported to be associated with higher nocturia levels [20], and we observed an interesting phenomenon in which the urine volume/water intake ratio dramatically increased in the rat model of experimental left varicocele (ELV); the decreases in hypothalamic

• Acknowledgements br Introduction The neurotransmitter glycin

  2022-01-15

  

  Acknowledgements Introduction The neurotransmitter glycine acts through two receptors: a strychnine-sensitive glycine receptor (GlyA) and a strychnine-insensitive glycine receptor (GlyB). GlyA is localized to the neuronal membrane post-synaptic to inhibitory glycinergic neurons, whereas GlyB is

• Materials and methods Standard curve for http

  2022-01-15

  

  Materials and methods Standard curve for methylglyoxal. Different concentrations (10, 25, 50, and 100μM) of pure MG (Sigma) were derivatized with 1,2-diaminobenzene and the absorbance of the resulting derivative was read by Cary 50 Bio UV-Visible spectrophotometer (Varian). One milliliter of total

• vivit mg We also demonstrated that inhibition of

  2022-01-15

  

  We also demonstrated that inhibition of NAAG hydrolysis to suppress glutamate production through a GCPII inhibitor is a viable target for cancer therapy. GCPII is also known as N-acetyl-L-aspartyl-L-glutamate peptidase I (NAALADase I) or NAAG peptidase (Pinto et al., 1996), and its increased express

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